Chelsea and Manchester United are on alert after Santos admitted Ganso could be sold this summer after contract talks broke down.
Both clubs have been monitoring the highly-rated 22-year-old for some time, as have the likes of Barcelona, Real Madrid, Porto, and Tottenham.
Santos had been keen for the Brazil international, who is under contract until 2015, to sign a longer-term deal to given them even greater security, but earlier this week he snubbed the offer put to him, which according to reports was worth around £30,000 a week.
Santos president Luis Alvaro Ribeiro has revealed Ganso will now be made available for transfer as a result of his contract snub.
And according to the Daily Mirror, Tottenham are ready to make their move for the highly-rated midfielder.
"Only Neymar is not negotiable," said Ribeiro.
"All other players, including Ganso, have the door open, depending on the proposals as they arise.
"If the will of Ganso is to leave, and there are clubs interested, then we are willing to listen to offers for him."
Ganso had earlier this week stated: "I didn't like the [contract] offer, I thought they would offer something better.
"Regardless of that, you have to keep your cool to play football and let things happen naturally.
"I don't know what can happen, only God knows it.
"I hope I can remain calm to keep playing football."