After choosing to swerve last week's China Super Series Premier due to a knee injury, Nehwal is back in action on Wednesday in the $350,000 event.
The 22-year-old, who recently won the Denmark Open and was a finalist at the French Open last month, has climbed to No. 3 in the world rankings and will be expecting a deep run in this tournament. She takes on Aprilla Yuswandari of Indonesia, whom she has beaten twice in the past, in Wednesday's opening singles contest.
Saina could face a tricky tie in quarter-finals if she progresses as expected, however, with China's seventh seed Yanjiao Jiang her likely opponent.
The Chinese have always posed problems for Nehwal and while Jiang holds a 5-0 record over her, she will be buoyed by the fact that she defeated Jiang's compatriot and world No. 1 Wang Yihan on her way to the title in Denmark.
Nehwal has won three Super Series titles this year so far - the Thailand Open, Indonesia Open and Denmark Open - as well as securing bronze at the London Olympic games and should be a force to be reckoned with in Hong Kong.