Liverpool v Manchester United takes place this afternoon in the Premier League.
The game, which takes place at Anfield, is scheduled to kick off at 13:30 BST and airs live in the UK on Sky Sports 1/Sky Sports 1 HD.
The game is Liverpool's first at home since the findings of an independent panel investigating the Hillsborough disaster were published last week.
The two clubs have held talks ahead of the game, and United manager Sir Alex Ferguson this week said was hoping for respect from everybody in attendance.
The Scot has appealed for fans not to show any "personal hatred" towards their counterparts, and in a letter that will be handed out to all United fans at the turnstiles, he wrote: "The great support you gave the team here last season has seen our allocation back up to near-full levels. I want you to continue that progress today.
"But today is about much more than not blocking gangways. Today is about thinking hard about what makes United the best club in the world.
"Our rivalry with Liverpool is based on a determination to come out on top – a wish to see us crowned the best against a team that held that honour for so long.
"It cannot and should never be based on personal hatred. Just 10 days ago, we heard the terrible, damning truth about the deaths of 96 fans who went to watch their team try and reach the FA Cup final and never came back.
"What happened to them should wake the conscience of everyone connected with the game.
"Our great club stands with our great neighbours Liverpool today to remember that loss and pay tribute to their campaign for justice. I know I can count on you to stand with us in the best traditions of the best fans in the game."
Liverpool captain Steven Gerrard believes the game is the biggest in club football and even bigger than Barcelona v Real Madrid.
"For me, it’s the biggest [game] because the Premier League is the biggest league in the world and these are the two most successful clubs," he told the club’s official website.
"I’m not being biased when I say that - I think Liverpool versus Man Utd is the biggest game. Maybe Barca and Madrid is up there close to that, but for me it’s still this one."
He added: "It’s a massive game – we’re looking for our first [league] win of the season and there would be no-one better for us to start getting three points on the board [against].
"Hopefully then we can go on a run of winning games and move up the league because our start to the season has been inconsistent."
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