The game, which takes place at the Liberty Stadium, is scheduled to kick off at 13:30 GMT and airs live in the United Kingdom on Sky Sports 1/Sky Sports 1 HD.
Swansea have won just one of their last nine league meetings against Man Utd, with that victory coming way back in January 1982.
League leaders Manchester United head to Wales on top of the tree again for Christmas, although it is only the eighth time under Sir Alex Ferguson that the Red Devils have been the Christmas number one.
Reports ahead of the game have suggested that United trio Rio Ferdinand, Paul Scholes and Ryan Giggs will leave the club at the end of the season, but speaking at his pre-match press conference, Sir Alex insisted he did not believe this would be the case.
It had been suggested that 38-year-old Scholes recently told friends about his intention to retire for a second time next summer, but Ferguson told reporters: "I would be surprised if Paul had spoken to someone without speaking to me - and he hasn't - so we can dismiss that.
"Ryan could play for another year or two. Rio has been terrific."
The Scot added: "The speculation comes from our policy of only giving older players one-year contracts."
Scholes and 39-year-old Giggs are on one-year deals, while Ferdinand, 34, is out of contract next summer and is yet to sign an extension.